Disulfide-Based Diblock Copolymer Worm Gels: A Wholly-Synthetic Thermoreversible 3D Matrix for Sheet-Based Cultures
نویسندگان
چکیده
منابع مشابه
Disulfide-Based Diblock Copolymer Worm Gels: A Wholly-Synthetic Thermoreversible 3D Matrix for Sheet-Based Cultures.
It is well-known that 3D in vitro cell cultures provide a much better model than 2D cell cultures for understanding the in vivo microenvironment of cells. However, significant technical challenges in handling and analyzing 3D cell cultures remain, which currently limits their widespread application. Herein, we demonstrate the application of wholly synthetic thermoresponsive block copolymer worm...
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Benzyl methacrylate (BzMA) is polymerized using a poly(lauryl methacrylate) macromolecular chain transfer agent (PLMA macro-CTA) using reversible addition-fragmentation chain transfer (RAFT) polymerization at 70 °C in n-dodecane. This choice of solvent leads to an efficient dispersion polymerization, with polymerization-induced self-assembly (PISA) occurring via the growing PBzMA block to produ...
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The recent development of polymerization-induced self-assembly (PISA) has facilitated the rational synthesis of a range of diblock copolymer worms, which hitherto could only be prepared via traditional post-polymerization processing in dilute solution. Herein we explore a new synthetic route to aqueous dispersions of cationic disulfide-functionalized worm gels. This is achieved via the PISA syn...
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Worm-like diblock copolymer nanoparticles comprising poly(glycerol monomethacrylate) (PGMA) as a stabilizer block and poly(2-hydroxypropyl methacrylate) (PHPMA) as a core-forming block were readily synthesized at 10% w/w solids via aqueous dispersion polymerization at 70 °C using Reversible Addition-Fragmentation chain Transfer (RAFT) chemistry. On cooling to 20 °C, soft transparent free-standi...
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Syndiotactic poly(methyl methacrylate) (sPMMA)-polybutadiene (PBD)—sPMMA triblock copolymers, or MBM, have been studied in the presence of o-xylene which is a selective solvent for the central PBD block. Syndiotactic PMMA is known to self associate in o-xylene. The central PBD sequence does not prevent the selfassociation of sPMMA from occurring. Actually, this phenomenon contributes to the sta...
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ژورنال
عنوان ژورنال: Biomacromolecules
سال: 2015
ISSN: 1525-7797,1526-4602
DOI: 10.1021/acs.biomac.5b01266